Calcium score association with paravalvular leakage in patients who underwent TAVR, the Mexican values

Jhonathan Uribe-Gonzalez, Departamento de Cardiología Intervencionista, Servicio de Cardiología, American British Cowdray Hospital; Departmento de Cardiología Intervencionista, Hospital de Cardiología de Centro Médico Nacional Siglo XXI; Facultad de Medicina, Universidad Nacional Autónoma de México. Ciudad de México, México
Daniela L. Leocachin-Parra, Departmento de Cardiología Intervencionista, Hospital de Cardiología de Centro Médico Nacional Siglo XXI; Facultad de Medicina, Universidad Nacional Autónoma de México. Ciudad de México, México
Jorge Torres-Rosales, Departmento de Cardiología Intervencionista, Hospital de Cardiología de Centro Médico Nacional Siglo XXI; Facultad de Medicina, Universidad Nacional Autónoma de México. Ciudad de México, México
Jhonathan Zamudio-Lopez, Departmento de Cardiología Intervencionista, Hospital de Cardiología de Centro Médico Nacional Siglo XXI; Facultad de Medicina, Universidad Nacional Autónoma de México. Ciudad de México, México
Efrain Arizmendi-Uribe, Departmento de Cardiología Intervencionista, Hospital de Cardiología de Centro Médico Nacional Siglo XXI; Facultad de Medicina, Universidad Nacional Autónoma de México. Ciudad de México, México
Guillermo Saturno-Chiu, Departmento de Cardiología Intervencionista, Hospital de Cardiología de Centro Médico Nacional Siglo XXI; Facultad de Medicina, Universidad Nacional Autónoma de México. Ciudad de México, México
Gela Pimentel-Morales, Departmento de Cardiología Intervencionista, Hospital de Cardiología de Centro Médico Nacional Siglo XXI; Facultad de Medicina, Universidad Nacional Autónoma de México. Ciudad de México, México
Óscar Millán-Iturbe, Departmento de Cardiología Intervencionista, Hospital de Cardiología de Centro Médico Nacional Siglo XXI; Facultad de Medicina, Universidad Nacional Autónoma de México. Ciudad de México, México
Joel Estrada-Gallegos, Departmento de Cardiología Intervencionista, Hospital de Cardiología de Centro Médico Nacional Siglo XXI; Facultad de Medicina, Universidad Nacional Autónoma de México. Ciudad de México, México

Objective: The objective is to determinate the association between the degree of aortic valve calcification and the presence of paravalvular leakage (PVL) in Mexican patients who underwent transcatheter aortic valve replacement (TAVR). Methods: We conducted a retrospective, analytic, cohort. Pooled data were retrospectively analyzed from the patient’s files from January 2014 to July 2022. With a median follow-up of 6 months. Results: We included 83 patients. 31 (37.3%) developed residual PVL. Several factors as male gender (men 58.1% versus women 41.9% p = 0.01), higher gradients previous TAVR (mean 57 mmHg in the group with versus mean 53 mmHg in the group without PVL, p = 0.01), bigger annulus diameters and perimeters as well as reduce left ventricular ejection fraction and a degree of aortic regurgitation previous TAVR were present more frequently in the group of residual PVL. Aortic valve calcification was the only predictor after the bivariate and multivariate analysis that showed an association with the presence of PVL after TAVR. The calculated cut-off value of calcium score was 2970 Agatston units, with a sensitivity of 70% and a specificity of 60% as a predictor for PVL. Conclusions: The results are consistent with the previous data and there are no greater differences in the Mexican population. The severity of the aortic valve calcification is an independent predictor of PVL in patients who underwent TAVR.

Keywords: Calcium score. TAVR. Paravalvular leakage. Mexican patients.