The rs4783961 and rs708272 genetic variants of the CETP gene are associated with coronary artery disease, but not with restenosis after coronary stenting




Gilberto Vargas-Alarcón, Departamento de Biología Molecular. Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México
Oscar Pérez-Méndez, Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
Rosalinda Posadas-Sánchez, Departamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México
Marco A. Peña-Duque, Subdirección de Proyectos de Innovación y Desarrollo, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México
Marco A. Martínez-Ríos, Departamento de Hemodinámica, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México
Hilda Delgadillo-Rodriguez, Interventional Cardiology. Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
José M. Fragoso, Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico


Objective: We evaluated whether cholesteryl ester transfer protein (CETP) gene polymorphisms are associated with the presence of coronary artery disease (CAD) and/or restenosis in patients with coronary stent. Methods: Two polymorphisms of the CETP gene [−971 A/G (rs4783961), and Taq1B A/G (rs708272)] were genotyped by 5’exonuclease TaqMan assays in 219 patients with CAD (66 patients with restenosis and 153 without restenosis) and 607 control individuals. Results: The distribution of polymorphisms was similar in patients with and without restenosis. However, when the whole group of patients (with and without restenosis) was compared to healthy controls, under dominant model, the G allele of the Taq1B A/G polymorphism was associated with increased risk of CAD (odds ratio [OR] = 1.48, pCDom = 0.032). In the same way, under codominant, dominant, and additive models, the A allele of the −971 A/G polymorphisms was associated with an increased risk of developing CAD (OR = 2.03, pCCo-dom = 0.022, OR = 1.83, pCDom = 0.008, and OR = 1.39, pCAdd = 0.011, respectively). In addition, the linkage disequilibrium showed that the “AG” haplotype was associated with increased risk of developing CAD (OR = 1.28, p = 0.03). Conclusion: This study demonstrates that CETP Taq1B A/G and CETP −971 A/G polymorphisms are associated with an increased risk of developing CAD, but no association with restenosis was observed.



Keywords: Genetics. High-density lipoprotein cholesterol. Coronary artery disease.