Relationship between oral microbiota dysbiosis and the atherosclerotic cardiovascular disease




Paulina Hernández-Ruiz, Unidad de Investigación UNAM-INC, Facultad de Medicina, Universidad Nacional Autónoma de México, Instituto Nacional de Cardiología Ignacio Chávez; División de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México; Ciudad de México, México
Hector González-Pacheco, Unidad de Cuidados Coronarios. Instituto Nacional de Cardiología Ignacio, Ciudad de México, México
Luis M. Amezcua-Guerra, Departamento de Inmunología, Instituto Nacional de Cardiología Ignacio Chávez. Ciudad de México, México
María A. Aguirre, Servicio de Clínica, Área de Investigación en Medicina Interna, Instituto de Medicina Traslacional e Ingeniería Biomédica, CONICET, Instituto Universitario del Hospital Italiano, Ciudad Autónoma de Buenos Aires, Argentina


Considering the high incidence of cardiovascular disease (CVD) worldwide, the present review provides a general panorama of the relation between the pathogenesis of these diseases and the development of periodontitis. Specific associations are described between an altered oral microbiota (and associated mechanisms) and the local and systemic immune response in patients with CVD. Additionally, the basis is established for considering an imbalance in the microbiota of the oral cavity as a potentially useful therapeutic target for the regulation of the immune response, which could possibly allow for better therapeutic outcomes in the case of patients with CVD.



Keywords: Oral microbiota. Cardiovascular disease. Periodontitis. Dysbiosis. Inflammation.